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2021 OMIG Abstract
Investigating Practice Patterns of Zoster Sine Herpete in the Zoster Eye Disease Study Group
George Sanchez1, Donald M. Miller1, Gregory Tsougranis1, Cong Phan1, Heavenly Zheng1, Bennie H. Jeng2, Elisabeth Cohen3, Michael E. Zegans1
1Dept. of Ophthalmology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; 2Dept. of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, 3NYU Grossman School of Medicine, NYU Langone Health, New York, NY
Purpose: To determine and compare differences in practice patterns related to diagnosis and treatment of zoster sine herpete (ZSH) amongst investigators in the Zoster Eye Disease Study Group in the United States, Canada, and New Zealand.
Methods: Participants of the Zoster Eye Disease Study (ZEDS) Group, spanning many locations across the United States and Canada, were surveyed regarding their clinical experience with ZSH in September 2021 with voluntary participation and sharing of information at the discretion of the surveyed physician. Clinical information currently being collected includes method of diagnosis, findings on initial exam, treatment undertaken, and overall clinical course. IRB approval was obtained.
Results: Upon initial query, ZSH is noted to be rarely diagnosed. Diagnosis of this disease varied across surveyed physicians with both serologic evidence as well as positive PCR on aqueous humor tap both used. One case demonstrated posterior segment complications, notably phlebitis, detected via fluorescein angiography. Initial data includes cases in which prolonged treatment was necessary as well as other cases with successful discontinuation of treatment. Up-to-date data will be presented at the November OMIG meeting by which time the survey will have been available to ZEDS investigators for two months.
Conclusions: ZSH is a rare disease entity that is infrequently diagnosed by cornea and uveitis specialists across the United States. Continued study of this disease entity will allow us to better understand proper diagnosis and management thereby informing future guidelines.
Disclosure: N
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